un événement autobiographie Alternative compex ras Poudre à canon Simuler siècle
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
The Importance of Mg2+‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants - Pálfy - Chemistry – A European Journal - Wiley Online Library
RAS(ON) Inhibitors | Revolution Medicines
The Ras switch in structural and historical perspective
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology
RAS(ON) Inhibitors | Revolution Medicines
Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange | PNAS
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife
The Ras switch in structural and historical perspective
Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | bioRxiv
Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer
Pharmaceuticals | Free Full-Text | A Rational Design of α-Helix-Shaped Peptides Employing the Hydrogen-Bond Surrogate Approach: A Modulation Strategy for Ras-RasGRF1 Interaction in Neuropsychiatric Disorders
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions | eLife
The Ras switch in structural and historical perspective
Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed Hydrolysis Reaction of Guanosine Triphosphate | Biochemistry
Simulating Ras: 30 years of progress - NCI
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling | Journal of Medicinal Chemistry
The Ras switch in structural and historical perspective
Frontiers | The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells