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un événement autobiographie Alternative compex ras Poudre à canon Simuler siècle

Raf promotes dimerization of the Ras G-domain with increased allosteric  connections | PNAS
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS

The Importance of Mg2+‐Free State in Nucleotide Exchange of Oncogenic K‐Ras  Mutants - Pálfy - Chemistry – A European Journal - Wiley Online  Library
The Importance of Mg2+‐Free State in Nucleotide Exchange of Oncogenic K‐Ras Mutants - Pálfy - Chemistry – A European Journal - Wiley Online Library

RAS(ON) Inhibitors | Revolution Medicines
RAS(ON) Inhibitors | Revolution Medicines

The Ras switch in structural and historical perspective
The Ras switch in structural and historical perspective

Integrated RAS signaling defined by parallel NMR detection of effectors and  regulators | Nature Chemical Biology
Integrated RAS signaling defined by parallel NMR detection of effectors and regulators | Nature Chemical Biology

RAS(ON) Inhibitors | Revolution Medicines
RAS(ON) Inhibitors | Revolution Medicines

Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric  modulation of switch loop dynamics | Scientific Reports
Phosphorylation promotes binding affinity of Rap-Raf complex by allosteric modulation of switch loop dynamics | Scientific Reports

Raf promotes dimerization of the Ras G-domain with increased allosteric  connections | PNAS
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS

The current state of the art and future trends in RAS-targeted cancer  therapies | Nature Reviews Clinical Oncology
The current state of the art and future trends in RAS-targeted cancer therapies | Nature Reviews Clinical Oncology

Approach for targeting Ras with small molecules that activate SOS-mediated  nucleotide exchange | PNAS
Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange | PNAS

Raf promotes dimerization of the Ras G-domain with increased allosteric  connections | PNAS
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | PNAS

Mapping the functional versatility and fragility of Ras GTPase signaling  circuits through in vitro network reconstitution | eLife
Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution | eLife

The Ras switch in structural and historical perspective
The Ras switch in structural and historical perspective

Binding of active Ras and its mutants to the Ras binding domain of  PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect
Binding of active Ras and its mutants to the Ras binding domain of PI-3-kinase: A quantitative approach to KD measurements - ScienceDirect

Raf promotes dimerization of the Ras G-domain with increased allosteric  connections | bioRxiv
Raf promotes dimerization of the Ras G-domain with increased allosteric connections | bioRxiv

Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as  Targets of Inactivation in Cancer
Cancers | Free Full-Text | Cutting the Brakes on Ras—Cytoplasmic GAPs as Targets of Inactivation in Cancer

Pharmaceuticals | Free Full-Text | A Rational Design of α-Helix-Shaped  Peptides Employing the Hydrogen-Bond Surrogate Approach: A Modulation  Strategy for Ras-RasGRF1 Interaction in Neuropsychiatric Disorders
Pharmaceuticals | Free Full-Text | A Rational Design of α-Helix-Shaped Peptides Employing the Hydrogen-Bond Surrogate Approach: A Modulation Strategy for Ras-RasGRF1 Interaction in Neuropsychiatric Disorders

BRET-based RAS biosensors that show a novel small molecule is an inhibitor  of RAS-effector protein-protein interactions | eLife
BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions | eLife

The Ras switch in structural and historical perspective
The Ras switch in structural and historical perspective

Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed  Hydrolysis Reaction of Guanosine Triphosphate | Biochemistry
Modeling the Role of G12V and G13V Ras Mutations in the Ras-GAP-Catalyzed Hydrolysis Reaction of Guanosine Triphosphate | Biochemistry

Simulating Ras: 30 years of progress - NCI
Simulating Ras: 30 years of progress - NCI

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide  Exchange Factor SOS1 and Modulate RAS Signaling | Journal of Medicinal  Chemistry
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling | Journal of Medicinal Chemistry

The Ras switch in structural and historical perspective
The Ras switch in structural and historical perspective

Frontiers | The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor  Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells
Frontiers | The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells